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What is Modalert?
Modalert is the generic form of Modafinil which is a wakefulness-promoting agent often used for the treatment of sleeping disorders and you can now purchase Modalert without a prescription. Modalert falls under the class of eugeroic drugs; this class of drugs main purpose is to prompt wakefulness in patients and individuals suffering from sleep disorders like sleep apnea, narcolepsy, excessive daytime sleepiness and shift work sleep disorder. It is been used vastly as a cognitive enhancing agent for patients suffering from ADHD and Neurological Fatigue in people suffering from multiple sclerosis. The effects of Modafinil is not a secret anymore, the user has reported Modalert to be one of the best generic brands so far. Drug enthusiastic agrees on including it in their biohacking tricks. Being the best cognitive agent it also gives non-scientific benefits such as,
- It boost energy in the body
- It is a mood enhancer
- It gives a sense of motivation
- It keeps you vigilant all day
- Helps improve your memory
- Helps you with good judgment
These are just the non-scientific uses, which are apparently known by user experiences. It is not just a drug but it has vast information about itself. Issues are been raised early concerning the addiction potential of Modalert, but unlike other nootropics, it does not over stimulate or gives a feeling of being “high”, so the concerned of Modalert being an addictive drug is next to null to very low.
How does it work?
Modalert’s mechanism of action is still undiscovered but we know these, that Modafinil affects the nervous systems of our brain. Modalert works on neurotransmitter to achieve effects of wakefulness and focus.
Orexin– Modalert works on Orexin also known as hypocretin, which is a neuropeptide that regulates wakefulness and alertness. Neurons that react to Orexin are found in the hypothalamus but even present in other numerous parts of the brain including the neurons that are responsible for sleep-wake cycle.
Briefly meaning Orexin is partially responsible for our sleep/wake cycle and hence has been associated with the study of narcolepsy. These neurons when activated increase the dopamine-norepinephrine in areas responsible for our wakefulness, and increases histamine in the brain. Studies on animal have shown that flawed Orexin system has to lead to a person being narcoleptic or lead to narcolepsy symptoms.
That being said it has been found that Modalert can still be effective even without the Orexin being functional, this being one explanation. So using Modalert may help you knock out your sleep-wake cycle temporarily. However, Modalert can make you feel disinterested towards eating as many of our cycles are linked together like appetite and sleep.
Dopamine– One of the very important ways Modalert is said to work is, by increasing the amount of dopamine in the brain. Dopamine is a neurotransmitter, which we relate to a sense of reward or any type of returns and is released when we perform any action consider as good e.g. buying a new book or eating chocolate. Interestingly dopamine is not required to make us feel good but it simply strengthens the involvement to increase our possibility of repeating those actions. When you take Modalert, it blocks the dopamine transporters in the brain, which are molecules that are responsible for removing dopamine from the synapses. This elevates the amount of dopamine offered for action, which increases wakefulness and activates the brain, just as caffeine does.
Histamine- another mechanism of Modalert is it increases the hypothalamic histamine levels. Histamine is a neurotransmitter which plays an important role in the sleep and wake cycle. A hypothalamus and tuberomammillary nuclei are where the histamine neurons are found and extend through the cortex and other regions. Whereas this is the reason why antihistamines are capable of making a person feel drowsy. Histamine can also influence erection with the use of H2 that blocks the histamine receptors causing low testosterone uptake.
Norepinephrine- it is very similar to adrenaline, which does the same thing as dopamine and histamine. It promotes wakefulness and improves attention. It mainly increased in the hypothalamus. In simple words, the brain believes that something important is going on and triggers a positive or negative response.
GABA- studies performed on rats have shown that Modalert also reduces the amount of GABA in posterior hypothalamus. GABA is also known to provide relaxation so partially we can say that the vigilance experience after taking Modalert is due to this particular effect.
Glutamate- glutamate elevate after taking Modalert. Glutamate is an excitatory neurotransmitter, which is raised as similar during caffeine intake. Actually, glutamate is considered the main excitatory neurotransmitter and is involved in many characteristics of normal cognitive purposes like memory and attention. Glutamate plays a vital role in long-term potentiating, which makes it significant in learning abilities.
What is Modalert been used for?
Modalert is an approved medication by the US FDA for the treatment of narcolepsy in 1998 and later for sleep apnea and shift work disorder in 2003, which is the intended use of this smart drug. Modalert has been used off- label for many purposes.
Narcolepsy– narcolepsy is a long-term neurological disorder, in which a person feels sleepy during the daytime. The most common symptoms of this disorder are excessive daytime sleepiness and unable to regulate sleep-wake cycles. Modalert helps prompt wakefulness during the day as well as helps regulates the sleep/wake cycle through pharmacological explanation involving histamine.
Sleep apnea– It is found that sleep apnea is the most common sleeping disorder in which 10 out eight experienced its symptoms. Further sleep apnea is categorized in three conditions, in which obstructive sleep apnea is the most common were a person experiences long to short breaks in breathing or stops breathing altogether for a fraction of seconds, which may prolong to even minutes. The GABA and histamine help relax the mind, which helps patients sleep without disturbance, as they have been awake all day after taking Modalert.
Shift work disorder– SWD is a circadian rhythm sleep disorder caused due to excessive daytime sleepiness in individuals who work on irregular schedules or on a rotational shift. A proper sleep-wake cycle is not attained due to irregular sleep patterns. Taking Modalert, prior starting your work shift or before whatever it intended to helps, you be wakeful and vigilant all day.
ADHD (off- label uses)
Attention deficit hyperactivity disorder is a neurodevelopment commonly found in children’s and teenagers and is likely to continue into adulthood. Modalert is a wakefulness agent, buy apart from that it, Modalert is well known as a cognitive enhancing agent. Patients suffering from ADHD are hyperactive, with a very short attention span and are very easily distracted. The dopamine, histamine and glutamate neurotransmitter helps achieve a state of vigilance and focus. Modalert is not an approved drug for the treatment of ADHD.
Neurological fatigue is a state of mind where a person feels exhausted, tired and low on energy. Modalert boosts energy and gives a sense of motivation, which helps patients suffering from fatigue with multiple sclerosis.
Modalert have many others off- label uses, but are not approved to bee prescript for the following disorders
- Attention deficit disorder
- Jet lag
- Fatigue in cancer patients and high-pressure jobs
- Memory problems related to Alzheimer’s disease
- Sleepiness caused by other prescription medications
- Treatment for cocaine addiction
- Parkinson’s disease
Chemical composition and dosage
Modalert is an oral drug and as proven to effective wakefulness- promoting agent. Modalert contains modafinil, which is not a secret, but the chemical composition for modafinil is excessively complex. The chemical name for modafinil is two [(diphenyl methyl) sulfinyl] acetamide and its molecular formula is C15H15NO2S with molecular weight 273.35. Modalert tablets contain 100mg or 200mg of modafinil and these inactive ingredients.
- Croscarmellose sodium
- Lactose monohydrate
- magnesium stearate
- Microcrystalline cellulose
- Pregelatinized starch
The prescript medication for sleep disorders is generally well tolerated and safe at a given dosage. Reports have been recorded that Modalert demonstrates neuroprotective and antioxidant properties while increasing the cortical pool. Modafinil 200 mg is normally the most prescript dose for a sleeping disorder.
Narcolepsy– 200mg tablet once a day, prior starting your day. In narcoleptic patients, it is advice to take 200 mg dosage so that they won’t feel exhausted or in a sleep deprived state.
Sleep apnea– A 100 mg or 200 mg dose once a day, depending on the symptoms. Modalert 200 mg can be broken into halves if you don’t get 100mg tablets.
SWD– for Shift work disorder Modalert should be taken prior 1hour before starting work shift. Suggested dose is of 200mg.
- Modalert can be taken with food or without food.
- Avoid taking Modalert with alcohol
- Consult with a doctor if you are pregnant or breastfeeding.
Modalert is a brand developed by Sun Pharma as an alternative to the US brand Provigil by Cephalon Inc. no matter how the seller promotes the effectiveness of a product; it is always safe to have the overall information about the experts behind the product. Modalert costs a fraction of the price compared to Provigil giving effective flawless effects. Each Modalert tablet is manufactured by Sun Pharmaceutical in India, containing 200 mg of peak quality modafinil.
There are many alternatives online for Modalert; Sun Pharma has maintained a loyal fan-base all over the world for the best quality modafinil. Due to the high pricing of Provigil, many previous users of Provigil have switched to Modalert. Sun Pharma is the world-renowned manufacturer of Modalert which have approval certifications from agencies like FDA (USA) EMA (Europe), MHRA (UK) TGA (Australia). Sun Pharma accounts over 70% sales from pharmaceutical markets outside India, from which 50% alone is accounted from the Unites States. Sun Pharma’s Modalert is the most popular generic version of Modafinil and we directly are sourced from Sun Pharma promising you with originality and cheap prices.
Research on Modalert
In 1998 FDA (Food and Drug administration) authorized Modalert for the treatment of narcolepsy, sleep apnea, and excessive sleep apnea. The mechanism of action of modafinil is unknown. Going through so many clinical trials, it was found that modafinil has a vast range of effective uses. Since the appearance of this smart drug in the pharmaceutical world it has been recognized as an effective drug to increase the brain performance in healthy individuals suffering from sleep deprivation. The effectiveness it gives has led to the great amount of researches and studies that plan to learn its specific effect on learning, general understanding, and knowledge acquirement. While the reports differ, the studies to prove the claims that this smart drug can improve the cognitive abilities are still in the process. The previous studies showed that Modalert 200 has an identical clinical profile to many other conservative stimulants, like methylphenidate (a drug mostly used for people suffering from ADHD and ADD). It can even consider that modafinil can also be used in the treatment of ADHD.
An early British clinical study published in 2002, this initiative to use it as an ADHD treatment by using several neuropsychological tests on sixty healthy individuals. These individuals are required to take 200mg each before carrying out specific tests to identify their memory and attention, the results of the tests inveterate the previous reports. Another British study has shown the different result in which an individual is given 200mg or more tend to overestimate their thinking abilities and which portray them as over confidence. In 2004 a research published in Canada were focused on ruling their own study gave them no important result whereas they found that this smart drug not only moved fatigue but also vigilance, energy and kept users motivated to finish the work.
Many other studies were conducted in which a study published in 2003 in Britain showed new discovers claiming that along with affecting the brain functions it had a greater impact on users mood. Similar to the Canadian study, when the lower dosage of modafinil was given to healthy individuals it was found it affected them especially with individuals with aggression and anxiety.
They performed another study which published in 2004 involving individuals aging from 50 to 70 years who didn’t experience sleep deprivation. Fascinatingly the reports didn’t show any increase brain activity or brain performance, which led to a conclusion that this smart drug is most effective on young healthy aged individuals.
A UK study held in 2005 found that its effects such as cognitive and as mood enhancer completely depended upon the user’s IQ. Several tests conducted on healthy college student 2-3 hours after taking the drug noticed that they normally persistent and improved their attention in terms of speed and vigilance. They found that the students with lower IQ showed slower effects and the brighter students benefited the most from it, in addition, they conducted wakefulness of the drug as a very important factor.
In the following year, another inconclusive research study was published on 60 young healthy students ranging from irrelevantly effective to performance enable ability. In the past years, researchers and studies have found Modalert to show effects on brain improvement, learning, and attention. Those students didn’t indicate any major side effects, which you can learn in the later parts of the article.
Development of Modalert
Modalert being the most popular nootropic has a unique history, of how it was developed. In the 1970s Lafon laboratories and Professor Michel Jouvet conducted an experiment in France which was the main origin of modafinil’s development. Modafinil begins with the invention of a sequence of benzhydryl sulfinyl compounds, with adrafinil. Adrafinil was first offered as an experimental treatment for narcolepsy in 1986 France. Modafinil is the main metabolite of adrafinil, missing the polar – OH bond on its terminal amide. Adrafinil when used for experimental treatment, it was reported that adrafinil took a longer time to show its effects. Adrafinil has to create a new substance in order to metabolize inside the body, later on, the newly created substances were named as Modafinil. It which is the brand name for Modafinil has been very popular in most countries were another brand such as Provigil is very expensive in compare to Modalert. Modafinil was considered to be a faster-acting stimulant as it doesn’t have to be broken down into another substance before it has any effect. Modalert today is one of the most used and prescript medication for on-label and off-label uses. Modafinil was approved by the US FDA for the treatment of narcolepsy in 1998 and for sleep apnea and shift work sleep disorder in 2003.
Who uses Modalert?
Modalert’s intended uses have been successfully witnessing effectively by all the patients suffering from the sleeping disorder. Apart from the intended uses of modafinil there a vast range of areas were Modalert is popular for its off-label uses. It is used by individuals from all walks of life; from people working in the corporate world and especially executives, students uses it during exams, new mothers, soldiers and even doctors.
The US Air Force army has named Modalert as the go pill for the militant pilots, so they can be alert in a sleep deprived state during important missions. Not only the Us Air Force but Indian Air Force, French Foreign Legion, UK Ministry of Defence and Us Tactical Paramedics have been using Modalert for the same purposes. Students use it as a cognitive enhancing agent to improve concentration and memory abilities. An oxford study shows that out of four, one student uses Modalert as a study pill.
Modalert has been compared to NZT-48 and CPH4 from the movies limitless and Lucy as it has been very popular among Silicon Valley and Wall Street bankers. It has reached till the white house too. Recent news and even by the Canadian medical association journal it was reported that astronauts use Modalert for long-term missions when they are on International Space Station.
Potential side effects
There are very rare drugs which show any side effects or even mild side effects with daily use. It is not yet reliably known accurately that Modalert even has any side effects. It is been used from the late 70s, and so far has not shown any severe side effects. But recent studies have found some side effects like
- Stomach Aches
- Dry Mouth
- Sore Throat
- Decrease In Appetite
There have been found some mood changes after taking the drug, like increased anxiety. There are cases where some serve side effects are seen after taking Modalert
- Skin rash (Stevens-Johnsons Syndrome)
- Persistent sleepiness
- Cardiovascular problems
In the case of experiencing any serious side effects seek medical help immediately. Informing your physician or chemist about your allergies before taking Modalert can be helpful to minimize side effects. Potential side effects may differ as every individual’s body reaction to a drug in a different way. Entirely, its effects are mainly positive with millions of loyal users worldwide who vow by the benefits of this drug.
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